Hit medical drama ER served up some of the most memorable romantic storylines of recent history, though they weren’t all great.

It’s a rare accomplishment for a TV show to be on air for a decade and a half, but ER is one of the few shows that managed to do so. The medical drama was one of the most successful shows in TV history, and it’s characters and storylines had a legitimate cultural impact that viewers and fans still remember today. Because the show was on for such an astonishingly long time, it gave the writers and cast the opportunity to develop fictional relationships with an exceptional amount of complexity, depth, and range. However, like most shows, some of those relationships were massive hits, while others were huge misses. Many of those relationships were memorable, but some were memorable for the right reasons while others were memorable for the wrong ones. So, which of the relationships on this long-running classic were amazing and unforgettable? And which ones do we just wish we could forget?

Best: Kerry Weaver & Sandy Lopez

ER: The 5 Best Couples In the Show’s History

ER: The 5 Best Couples In the Show’s History

One of the best things about ER was that it tackled so many ideas and social issues that TV had never really confronted before. And, although it might seem downright normal now, there was a time where showing gay characters and relationships on TV was pretty much unheard of. But ER made a bold move introducing Kerry Weaver, a main character who happened to be a lesbian, and they made even bolder moves by introducing her relationship with Sandy Lopez. It was one of the first times mainstream TV featured a main character who was gay at all, and giving her relationship with Sandy the same weight as every other relationship on the show was a landmark achievement.

Best: Mark Green & Susan Lewis

ER: The 5 Best Couples In the Show’s History

ER: The 5 Best Couples In the Show’s History

During its exceptionally long tenure on-air, ER loved to play with the will they/won’t they relationship dynamic. Although their relationship ended on “won’t they”, the relationship between Mark and Susan was one of the show’s best. Dr. Greene and Dr. Lewis spent almost their entire relationship as best friends, but there was always the underlying tension of whether or not things would develop into more. And although both characters proclaimed their love for one another, ultimately, things didn’t work out. However, the chemistry between the actors as well as the legitimate friendship between the two makes it one of the best relationships on the show.

Best: Luka Kovac & Abby Lockhart

ER: The 5 Best Couples In the Show’s History

ER: The 5 Best Couples In the Show’s History

All of the long-running main characters of ER went through some serious journeys throughout the show, and two of the most epic odysseys belonged to Abby Lockhart and Luka Kovac. Luka and Abby were kind of the Doug and Carol of ER’s later years; they were on and off and had a ton of ups and downs, but they always seemed to be drawn back to one another. So then, it’s no surprise that they wound up together in the end. Individually the characters were kind of a mess, but after years of growth on their own and together, their relationship became one of the best parts of the series.

Best: Mark Greene & Elizabeth Corday

ER: The 5 Best Couples In the Show’s History

ER: The 5 Best Couples In the Show’s History

Over the course of his character’s development, Dr. Mark Greene wasn’t particularly lucky in love. He seemed to try his best, but after a series of failed relationships and almost relationships, he finally managed to work it out. Once he met Dr. Elizabeth Corday, it seemed like everything was coming up roses for the couple. Their relationship was sweet and solid, and it seemed like they were in it for the long haul, which they ultimately were. Sadly, Dr. Greene discovered that he was dying of brain cancer, and his love with Elizabeth wound up being his last. The ER writers definitely loved torturing the audience with this one!

Best: Doug Ross & Carol Hathaway

ER: The 5 Best Couples In the Show’s History

ER: The 5 Best Couples In the Show’s History

I mean, who else could possibly top this list? It’s pretty unusual to have a universally loved fictional relationship, but Doug and Carol fit that bill to a T. The whole world knew they were meant to be together, and the show mercifully agreed, even if they dragged out the torturous drama as long as they possibly could. As individuals, Doug and Carol were messes, and their relationship was often times a mess—but they were just meant to be! Heck, even George Clooney thought so. Reportedly, he agreed to make an appearance in Carol’s last episode specifically because he always wanted the pair to get back together. Obviously, we feel you, George.

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