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When Barry and Iris deal with the loss of their daughter, the team faces their greatest threat yet – one that threatens to destroy all of Central City; Killer Frost has a brush with death that will change her relationship with Caitlin. Faced with the news of his impending death, Barry’s resiliency suffers as he struggles to fight fate; Cecile’s career as a D.A. conflicts with her identity when she crosses paths with a villainous meta-human. Barry prepares a member of Team Flash for life without him while hunting a terrifying meta-human with an unquenchable thirst; Ralph uncovers a family secret.